Grey's Anatomy Season 22 Trailer: Explosive Twists and Medical Crises

Grey’s Anatomy Season 22 premieres on October 9, 2025, filled with hospital crises, intense drama, and the aftermath of the cliffhanger. Expect life-or-death decisions.

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Grey Sloan Memorial faces chaos after the explosion. Grey’s Anatomy Season 22 brings new and old characters, while the team deals with emotional turmoil and medical crises.

What’s New in Grey's Anatomy Season 22?

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Grey’s Anatomy Season 22 Cast Updates

Meredith Grey returns with a smaller role. Chandra Wilson, James Pickens Jr., and Scott Speedman are back, joined by new characters like Simone Griffith and Winston Ndugu.

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How Will the Explosion Affect Grey Sloan's Staff?

After the catastrophic explosion, Grey Sloan’s staff faces emotional turmoil and makes life-or-death decisions. Relationships will be tested as hospital renovations begin.

Image © 2025 ABC / Shonda Rhimes / Disney

When Does Grey's Anatomy Season 22 Premiere?

Grey’s Anatomy Season 22 premieres on October 9, 2025, at 10/9c on ABC. Episodes will be available on Hulu the next day. Get ready for intense drama!

Image © 2025 ABC / Shonda Rhimes / Disney

How Many Episodes Will There Be in Season 22?

Grey’s Anatomy Season 22 will have 18 episodes. Key episodes like “Only the Strong Survive” and “We Built This City” focus on the hospital’s recovery and challenges.

Image © 2025 ABC / Shonda Rhimes / Disney

Catch All the Details of Grey’s Anatomy Season 22

For a full breakdown of the cast, episodes, and trailer, check out our detailed article on everything you need to know about Grey’s Anatomy Season 22.

Image © 2025 ABC / Shonda Rhimes / Disney